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In 1572, oprichnik Gryaznoy loves Marfa, who is betrothed to Lykov, and seeks a potion to make her love him. His former mistress Lyubasha obtains another potion from the Tsar’s physician, Bomelius. At a feast, Gryaznoy gives Marfa what he believes is a love potion, but Lyubasha has substituted poison. Ivan the Terrible chooses Marfa as his bride. She becomes gravely ill; Lykov is executed, and Gryaznoy learns that the potion killed Marfa. Lyubasha confesses, and Gryaznoy kills her. In her delirium, Marfa mistakes Gryaznoy for Lykov and dies.
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